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KMID : 0603820110170040347
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Journal of Experimental & Biomedical Science
2011 Volume.17 No. 4 p.347 ~ p.353
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The Sst Ⅰ Restriction Fragment Length Polymorphism of the Apolipoprotein C-Ⅲ Gene in Korean Subjects
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Youk Hyei-Soo
Kim In-Sik
Kang Sang-Sun
Kang Hee-Gyoo
Hyun Sung-Hee
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Abstract
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The definite mechanism in the control of triglyceride metabolism is not well understood. Nowadays, it has been known that the polymorphism of apolipoprotein C-Ⅲ Sst Ⅰ was an important candidate for contributing to the control of triglyceride metabolism. In 298 Korean women aged 30 years or more, the genotypes of apolipoprotein C-Ⅲ Sst Ⅰ were statistically compared with total blood cholesterol, triglyceride, high density lipoprotein, fasting blood sugar and hemoglobin A1c. Multiple logistic regression analysis was carried out to compare the odd-ratios of hypertriglyceridemia, hypercholesterolemia and diabetes mellitus with them. The differences among the polymorphic types (S₁S₁, S₁S₂, and S₂S₂) were not statistically significant in the distribution of triglyceride, total cholesterol, high density lipoprotein, fasting blood sugar, and hemoglobin A1c. There were not statistically significant in the odds ratios of the hypertriglyceridemia, hypercholesterolemia, and diabetes mellitus, neither. Those were not statistically significant. This study did not show that there was any association between the polymorphism of apolipoprotein C-Ⅲ Sst Ⅰ and various laboratory values-total blood cholesterol, triglyceride, high density lipoprotein, fasting blood sugar and hemoglobin A1c.
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KEYWORD
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Apolipprotein, ApoC-Ⅲ, Hypercholesterolemia, Hypertriglyceridemia, Diabetes, RFLP, Sst Ⅰ, Triacylglycerol
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